Fibrillar type I collagen plays a key role in bone, skin, and tendon formation, providing tissues with the necessary structural support. Our findings provide an important insight into the process of procollagen trafficking and reveal a short-loop pathway from the ER to the Golgi, without the use of large carriers.Ĭollagen is the most abundant protein in the body. We propose a short-loop model of COPII-dependent ER-to-Golgi traffic that, while consistent with models of ERGIC-dependent expansion of COPII carriers, does not invoke long-range trafficking of large vesicular structures. Large GFP-positive structures were observed occasionally, but these were nondynamic, are not COPII positive, and are labeled with markers of the ER. Here, analyzing endogenous procollagen and a new engineered GFP-tagged form, we show that transport to the Golgi occurs in the absence of large (>350 nm) carriers. Owing to the size of fibril-forming procollagen molecules it is assumed that they are transported from the endoplasmic reticulum to the Golgi in specialized large COPII-dependent carriers. Defects in the assembly of a collagen matrix lead to pathologies including fibrosis and osteogenesis imperfecta.
#Free download manager plugin 1.5.7.6 mod#
In-game mod options menu (see MCM Integration below).Secretion and assembly of collagen are fundamental to the function of the extracellular matrix. Ability to host tournaments in your owned towns: These cost 2000 gold and can only be hosted once a week. Disabled base game daily random tournament spawning (all tournament spawns are handled by triggers). All new tournaments will be communicated to the player either through the game log for less important tournaments or through the scroll thing that appears at the top of the screen for tournaments underlining more important events (Notifications can be disabled). Local nobles will call tournaments to celebrate the birth of their lord's children. Local nobles will call tournaments to celebrate the weddings of their lords. Faction leaders will call tournaments in their towns to celebrate peace agreements made with previously enemy factions. Cities already hosting unresolved tournaments will not experience this. City folk need entertainment and they will dip into the clan coffers (2000 gold) to do this. Local nobles will call tournaments because of high prosperity (8% daily chance above 5000 prosperity). 
Low renown players (Some tournament types will affect loyalty, prosperity, security and food stocks in settlements.Some tournament types will affect relations with local notables.Tournament rewards have been expanded and improved to scale based on player renown.
Increased renown gain on tournament win (new default is 10). Modified XP gain on hit to be 100% of normal instead of 25%. Winning tournaments will now grant a chunk of bonus xp in a tournament skill (e.g one-handed or athletics). Some of these guys have beastly stats and make tournaments way more challenging and fun. Tournament participants will now include lords of the faction and associated heroes far more often. This is the way this mod is meant to be played. Default tournament AI difficulty is maxed out. Ability to select from 5 generated prizes where the tier is based on your renown before joining a tournament. Lord tournaments where a faction leader invites all his lord for a high stakes high reward tournament. Bring your companions and spouse into tournaments with you and team up with them (when possible) if they are in your party. Different triggers will have different effects on the settlement holding the tournament. Tournaments are now triggered by various events happening on the campaign map instead of just randomly appearing. As a participant, it gives you far better XP and item rewards (based on your renown). As a lord, they can help you increase your settlement's stats at the expense of gold and food stocks, while gaining favor with the local notables. In turn, however, they are also far more rewarding. In terms of balancing, the default settings of this mod make tournaments a lot more challenging for the average player. Tournaments Enhanced is also customizable! Installing Mod Configuration Menu (MCM) enables the in-game mod options screen. The mod modifies and adds new tournament contestants, rewards, impacts on the overall campaign, impacts on relationships with local nobles, XP and stat gains, how tournaments are created, events related to tournaments, tournament difficulty, and more.
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